Thermo Fisher Scientific TLR2 Recombinant Rabbit Monoclonal Antibody (JM22-41)
TLR2 단백질을 인식하는 재조합 토끼 단일클론 항체로, 높은 특이성과 감도를 제공. Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용에 적합. HEK293 발현 시스템에서 생산되며, 일관된 로트 품질과 동물 유래 성분이 없는 포뮬레이션 제공.
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Thermo Fisher Scientific TLR2 Recombinant Rabbit Monoclonal Antibody (JM22-41)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 4 publications |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 | View 2 publications |
| Flow Cytometry (Flow) | 1:50–1:100 | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM22-41 |
| Immunogen | Recombinant protein within Human TLR2 (aa 21–588) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2810063 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits, followed by screening individual clones to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to larger rabbit immune repertoire
Target Information
TLR2 is a member of the Toll-like receptor (TLR) family, playing a key role in pathogen recognition and activation of innate immunity.
TLR2 forms heterodimers with TLR1 or TLR6 to recognize bacterial and mycoplasma lipoproteins. It activates kinases and transcription factors such as PKCα/β and NF-κB via adaptor molecules MyD88 and TIRAP.
TLR2 is most abundantly expressed in peripheral blood leukocytes and mediates host responses to Gram-positive bacteria and yeast.
Expression is highest in CD14+ monocytes, followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells.
Regulation varies by immune modifiers: LPS, GM-CSF, IL-1, and IL-10 upregulate TLR2, while IL-4, IFN-γ, and TNF downregulate its expression in monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: MA5-32787_TLR2_O60603-1_Rabbit.svg, MA5-32787_TLR2_O60603-1_Rabbit_PDP.jpeg)
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