Thermo Fisher Scientific Phospho-Tachykinin Receptor 3 (Thr389, Thr390) Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:1,000

Product Specifications

Target Information

The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B. These act on three related but distinct seven-transmembrane G-protein coupled receptors at different concentrations.
The NK-3 receptor (NK3R) has the greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Upon ligand binding, NK3R activates a phosphatidylinositol-calcium second messenger system, likely leading to the release of vasopressin and oxytocin into circulation.
NK3R may play a role in learning and memory, as mice lacking this gene exhibit cognitive deficits. Although NK3R has been suggested to regulate vagal afferent relay neurons, it is more likely activated by substance P or neurokinin A, since airway nerves do not express neurokinin B.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.