Thermo Fisher Scientific Phospho-Tachykinin Receptor 3 (Thr389, Thr390) Polyclonal Antibody
인간 NK3 수용체 Thr389/Thr390 인산화 부위를 인식하는 토끼 폴리클로날 항체. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 1 mg/mL 농도, 4°C 단기 보관 및 -20°C 장기 보관 권장.
- 카탈로그번호
- 7TM0362A
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
- Western Blot (WB): 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human NK3 around the phosphorylation site of Thr389/Thr390 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco's PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B. These act on three related but distinct seven-transmembrane G-protein coupled receptors at different concentrations.
The NK-3 receptor (NK3R) has the greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Upon ligand binding, NK3R activates a phosphatidylinositol-calcium second messenger system, likely leading to the release of vasopressin and oxytocin into circulation.
NK3R may play a role in learning and memory, as mice lacking this gene exhibit cognitive deficits. Although NK3R has been suggested to regulate vagal afferent relay neurons, it is more likely activated by substance P or neurokinin A, since airway nerves do not express neurokinin B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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