Thermo Fisher Scientific Phospho-Tachykinin Receptor 3 (Ser398, Ser399) Polyclonal Antibody
인산화된 Tachykinin Receptor 3(Ser398/Ser399)을 인식하는 토끼 폴리클로날 항체로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태입니다. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- 7TM0362B
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human NK3 around the phosphorylation site of Ser398/Ser399. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The tachykinins are a family of small peptides including neurotransmitters such as substance P, neurokinin A, and neurokinin B. These act on three distinct seven-transmembrane G protein-coupled receptors at varying concentrations.
The NK-3 receptor (NK3R) shows the highest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Upon ligand binding, NK3R activates a phosphatidylinositol-calcium second messenger system, likely triggering the release of vasopressin and oxytocin. NK3R may also play roles in learning and memory, as knockout mice show cognitive deficits. Although NK3R has been suggested to regulate vagal afferent relay neurons, these receptors are more likely activated by substance P or neurokinin A since airway nerves do not express neurokinin B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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