Thermo Fisher Scientific ROR1 Polyclonal Antibody
ROR1 단백질을 표적으로 하는 Thermo Fisher Scientific의 폴리클로날 항체. 인간, 생쥐, 랫드 반응성. Western blot 및 ELISA에 적합. KLH 결합 합성 펩타이드(aa 301-360) 면역원 사용. 단백질 A 정제, 액상 형태, -20°C 보관.
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Thermo Fisher Scientific ROR1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:1,000 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human ROR1, amino acids 301–360 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated surface protein predominantly expressed during embryogenesis, playing roles in organ morphogenesis, nervous system development, and neural progenitor maintenance. It is virtually absent from normal adult tissues except for low-level expression in immature B cell precursors and adipocytes. ROR1 is overexpressed in several malignancies, including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, and lung adenocarcinoma.
Initially identified in neuroblastoma cell lines, ROR1 was classified as an orphan receptor until Wnt-5a was suggested as a potential ligand. ROR1 functions as a pseudokinase, promoting proliferation and resistance to apoptosis through interactions with Wnt-5a and TCL1-mediated AKT activation. Structurally, ROR1 is a glycoprotein with extracellular Ig-like, Frizzled, and Kringle domains, and an intracellular tyrosine kinase domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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