Thermo Fisher Scientific PAGR1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL
• Suggested positive control: EL4 cell lysate
• Can be used with blocking peptide PEP-0942

Product Specifications

Target Information

Steroid receptor co-activators (SRCs) were initially described as nuclear receptor transcription co-activators but are now known to co-regulate transcription initiated by other transcription factors.
GAS is a glutamate-rich protein that interacts with SRC1, but not GRIP1 or AIB1. It also interacts specifically with the alpha subunit of the estrogen receptor (ERα).
Depletion of GAS in MCF7 cells reduces mRNA and protein levels of ER target genes such as pS2, c-Myc, and cyclin D1, highlighting its regulatory role in estrogen signaling.
Additionally, GAS associates with an SET1-like methyltransferase complex specific for H3K4 methylation, suggesting multiple roles in transcriptional regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.