Thermo Fisher Scientific PAGR1 Polyclonal Antibody
PAGR1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot에 적합합니다. Human 및 Mouse 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 2–8°C 보관 시 안정적입니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
- Suggested positive control: EL4 cell lysate
- Can be used with blocking peptide PEP-0942
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide from near the carboxy terminus of human GAS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | 2–8°C for up to 3 months; for long-term storage, store at -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152704 |
Target Information
Steroid receptor co-activators (SRCs) were initially described as nuclear receptor transcription co-activators but are now known to co-regulate transcription initiated by other transcription factors.
GAS is a glutamate-rich protein that interacts with SRC1, but not GRIP1 or AIB1. It also interacts specifically with the alpha subunit of the estrogen receptor (ERα).
Depletion of GAS in MCF7 cells reduces mRNA and protein levels of ER target genes such as pS2, c-Myc, and cyclin D1, highlighting its regulatory role in estrogen signaling.
Additionally, GAS associates with an SET1-like methyltransferase complex specific for H3K4 methylation, suggesting multiple roles in transcriptional regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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