Thermo Fisher Scientific Phospho-ASK1 (Thr918) Polyclonal Antibody
인간 MAP3K5(ASK1) Thr918 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot 및 ELISA에 적합하며, 높은 특이성과 민감도를 제공. 액상 형태로 공급되며 -20°C에서 안정적으로 보관 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around T918 of human MAP3K5 (Q59GL6) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 4.52 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901800 |
Product Specific Information
- Positive Samples: HeLa
- Immunogen sequence: TETFT
Target Information
MAP3K5 (ASK1) is a serine/threonine kinase abundantly expressed in human heart and pancreas. It is activated by various extracellular stimuli, including cytokines, growth factors, and environmental stresses. ASK1 activates MKK4 and MKK6, which subsequently activate JNK and p38 MAP kinases. ASK1/MAPKKK5 activation occurs via TNFR and Fas through interaction with TRAF family members and Daxx. Overexpression of ASK1 induces apoptosis, while its inactive form inhibits TNF-α-induced apoptosis. ASK1 is widely expressed in human and mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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