Thermo Fisher Scientific LRP5 Monoclonal Antibody (2B11)
인간 LRP5 단백질을 인식하는 마우스 단클론 항체로, WB, Flow Cytometry, ELISA에 적합합니다. 비결합형 형태이며 1 mg/mL 농도로 제공됩니다. Protein G로 정제되어 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific LRP5 Monoclonal Antibody (2B11)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2B11 |
| Immunogen | Purified recombinant fragment of human LRP5 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538584 |
Product Specific Information
MA5-17113 targets LRP5 in FACS, indirect ELISA, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human LRP5 expressed in E. coli.
MA5-17113 detects LRP5, which has a predicted molecular weight of approximately 179 kDa.
Target Information
LDL-related proteins LRP5 and LRP6 are members of the LDL receptor superfamily involved in the canonical Wnt signaling pathway.
Mammalian LRP6 binds to Wnt1 and enhances Wnt-induced developmental processes in Xenopus embryos.
Mice lacking LRP6 exhibit developmental defects similar to those caused by deficiencies in various Wnt proteins.
Wnt proteins induce binding of LRP5 to Axin, leading to Axin degradation and beta-catenin stabilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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