Thermo Fisher Scientific SF3A1 Monoclonal Antibody (OTI7G6), TrueMAB
Human SF3A1 단백질(아미노산 249-568)을 항원으로 한 Mouse IgG2a 단일클론 항체. Western blot에 최적화되어 있으며, 고순도 친화 크로마토그래피 정제. PBS/BSA/glycerol buffer에 보관, -20°C에서 안정적 유지.
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Thermo Fisher Scientific SF3A1 Monoclonal Antibody (OTI7G6), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7G6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 249–568 of human SF3A1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer (subunits 1, 2, and 3) is essential for converting 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing.
Subunit 1 belongs to the SURP protein family, characterized by SURP motifs involved in RNA binding. It has tandem SURP motifs in the N-terminal half and a proline-rich plus ubiquitin-like domain in the C-terminal region.
Binding studies show that SURP motifs are necessary for interaction with subunit 3, while contacts with subunit 2 may occur through sequences C-terminal to the SURP motifs.
Alternative splicing produces multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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