Thermo Fisher Scientific NRG1 Monoclonal Antibody (03)
Human NRG1-beta1 중심 부위에 대응하는 합성 펩타이드로 제작된 Mouse IgG2b 단클론 항체. Western blot에 1:500~1:2,000 희석 비율로 사용 가능. Protein A 정제, 보존제 무첨가 PBS 용액 형태. Human NRG1-alpha와 교차 반응 없음.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 03 |
| Immunogen | Synthetic peptide corresponding to the center region of the human NRG1 isoform beta 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866572 |
Product Specific Information
- No cross-reactivity in WB with Human NRG1-alpha.
Target Information
Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. A variety of different isoforms are produced from the NRG1 gene by alternative splicing, including heregulins (HRGs), glial growth factors (GGFs), and sensory and motor neuron-derived factor (SMDF).
These isoforms are tissue-specifically expressed and differ significantly in structure. HRG isoforms contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains; GGF and GGF2 isoforms include a kringle-like sequence plus Ig and EGF-like domains; SMDF isoform shares only the EGF-like domain with other isoforms.
All NRG1 isoforms interact with ERBB family tyrosine kinase transmembrane receptors, inducing growth and differentiation of epithelial, neuronal, glial, and other cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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