Thermo Fisher Scientific Human PD-1 His-tag Recombinant Protein

Thermo Fisher Scientific Human PD-1 His-tag Recombinant Protein

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitution: Dissolve the protein in sterile double-distilled water to a concentration of 0.2 mg/mL or lower.
• It is recommended that the protein be aliquoted and used as soon as possible.
• Store aliquots under sterile conditions at -20°C.
• Avoid repeated freeze-thaw cycles.

Target Information

Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC).
Activated T cells express receptors such as PD-1 (PDCD-1) that mediate inhibitory signals from APCs.
PD-1 binds ligands PDL-1 and PDL-2, generating inhibitory signals that suppress immune activation in the absence of danger signals (e.g., LPS or bacterial molecules).
PD-1 knockout mice exhibit hyperactivated immune systems and autoimmune diseases.
Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.