Thermo Fisher Scientific FGFR3 Monoclonal Antibody (07)
Human FGFR3 단백질을 인식하는 Mouse monoclonal antibody로, IHC(P)에서 1:50–1:200 희석 비율로 사용 가능. 보존제가 없는 액상 형태이며, Protein A로 정제됨. FGFR3 관련 연구 및 질병 기전 분석에 적합.
- 카탈로그번호
- MA529274
- 판매단위
- pk
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) [IHC(P)]: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 07 |
| Immunogen | A synthetic peptide corresponding to the center region of the Human FGFR3/CD333 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785168 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human FGFR3/CD333.
Target Information
FGFR3 is a member of the FGFR family of receptor tyrosine kinases that regulate key cellular functions such as angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair.
FGFR family members are implicated in diseases including cancer, rheumatoid arthritis, and diabetic retinopathy.
A full-length FGFR3 protein includes an extracellular region with three immunoglobulin-like domains, a single transmembrane segment, and a cytoplasmic tyrosine kinase domain.
The extracellular region interacts with fibroblast growth factors, initiating downstream signaling that influences mitogenesis and differentiation.
FGFR3 plays a critical role in bone development and maintenance. Mutations in this gene are associated with craniosynostosis and various skeletal dysplasias.
Three alternatively spliced transcript variants encoding different protein isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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