Thermo Fisher Scientific FGFR3 Monoclonal Antibody (07)

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) [IHC(P)]: 1:50–1:200

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human FGFR3/CD333.

Target Information

FGFR3 is a member of the FGFR family of receptor tyrosine kinases that regulate key cellular functions such as angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair.
FGFR family members are implicated in diseases including cancer, rheumatoid arthritis, and diabetic retinopathy.
A full-length FGFR3 protein includes an extracellular region with three immunoglobulin-like domains, a single transmembrane segment, and a cytoplasmic tyrosine kinase domain.
The extracellular region interacts with fibroblast growth factors, initiating downstream signaling that influences mitogenesis and differentiation.
FGFR3 plays a critical role in bone development and maintenance. Mutations in this gene are associated with craniosynostosis and various skeletal dysplasias.
Three alternatively spliced transcript variants encoding different protein isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.