Thermo Fisher Scientific CD136 (RON) Polyclonal Antibody
Human CD136 (RON) 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합. 항원 친화 크로마토그래피로 정제된 액상 시약이며, 세포막 위치 단백질 검출에 유용. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide containing epitope EPYYS without phosphorylation surrounding Y1238/9 of human CD136 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human stomach tissue
- Cellular location: Membrane
Target Information
MST1R (RON) is a receptor tyrosine kinase involved in cell proliferation and motility. It is a membrane-spanning, disulfide-linked heterodimer resulting from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding induces tyrosine phosphorylation of the beta chain. Knockout studies show MST1R/RON (-/-) mice fail to survive past the periimplantation period. The MST1R/RON gene is mapped to 3p21, a region frequently altered in small cell lung and renal carcinoma, and is implicated in epithelial cancer progression. Expression is documented in many normal human tissues, with ESTs isolated from normal and cancerous colon, mouth, prostate, stomach, and uterus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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