Thermo Fisher Scientific MBP Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive control: Brain tissue (Hippocampus)
• Cellular location: Myelin membrane

Target Information

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. MBP-related transcripts are also present in the bone marrow and immune system. These arise from the long MBP gene (also called Golli-MBP), which contains three additional exons upstream of the classic MBP exons.

Alternative splicing from the Golli and MBP transcription start sites gives rise to two sets of MBP-related transcripts and gene products:

1. Golli mRNAs – contain three unique exons spliced in-frame to one or more MBP exons, encoding hybrid proteins with N-terminal Golli sequence linked to MBP sequence.
2. MBP-only transcripts – contain only MBP exons and produce the well-characterized myelin basic proteins.

This complex gene structure is conserved among species, suggesting that the MBP transcription unit is an integral part of the Golli transcription unit, important for gene function and/or regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.