Thermo Fisher Scientific HECW1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human HECW1. Recombinant protein control fragment (Product #RP-89679). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HECW1,uniProtId:Q76N89-1,ncbiNodeId:9606,antigenRange:356-481,antigenLength:1606,antigenImageFileName:PA5-64914_HECW1_Q76N89-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64914_HECW1_Q76N89-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2663811

Product Specific Information

Immunogen sequence: STEPESAQIQD SPMNNLMESG SGEPRSEAPE SSESWKPEQL GEGSVPDGPG NQSIELSRPA EEAAVITEAG DQGMVSVGPE GAGELLAQVQ KDIQPAPSAE ELAEQLDLGE EASALLLEDG EAPAS

Highest antigen sequence identity to the following orthologs - mouse 45%, rat 44%.

Target Information

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.