Thermo Fisher Scientific CD59 (Protectin) Monoclonal Antibody (OV9A2), FITC, eBioscience
인간 CD59(Protectin)을 인식하는 OV9A2 단클론 항체로, FITC 형광 표지되어 흐름세포분석에 최적화됨. 세포막 공격복합체 형성을 억제하는 CD59 검출에 사용. 488 nm/520 nm 파장에서 Blue Laser에 적합하며, 4°C 암소 보관.
- 카탈로그번호
- 11-0596-42
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD59 (Protectin) Monoclonal Antibody (OV9A2), FITC, eBioscience
Thermo Fisher Scientific CD59 (Protectin) Monoclonal Antibody (OV9A2), FITC, eBioscience™
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.125 µg)/test
Publications: View 5 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OV9A2 |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10717243 |
Additional Formats:
- APC
- APC-eFluor 780
- PE
- PE-Cyanine7
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Request custom conjugation
Product Specific Information
This OV9A2 monoclonal antibody reacts with human CD59 (Protectin), a GPI-linked membrane glycoprotein homologous to the murine Ly-6 superfamily. CD59 is expressed on all human lymphocytes, monocytes, granulocytes, erythrocytes, and non-hematopoietic cells including endothelial cells and neurons.
CD59 binds complement components C8 and C9, inhibiting membrane attack complex assembly and complement-mediated cytolysis. It interacts with CD2 to modulate T-cell adhesion and activation. Altered CD55/CD59 expression is observed in systemic lupus erythematosus (SLE).
Crossblocking studies indicate OV9A2 binds the same epitope as MEM-43.
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and tested on normal human peripheral blood cells
Recommended use: 5 µL (0.125 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test)
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD59 (Protectin) is an 18–20 kDa GPI-anchored inhibitor of the membrane attack complex (MAC), protecting autologous cells from complement-mediated lysis. It associates with the C5b-8 complex to prevent cytolytic pore formation.
CD59 also acts as a low-affinity ligand for CD2, contributing to T-cell costimulation and signal transduction. Mutations cause CD59 deficiency, leading to hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.