Thermo Fisher Scientific NUP98 Recombinant Rabbit Monoclonal Antibody (2H4)
NUP98 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간 시료 반응성이 있으며, 고순도 친화 크로마토그래피 정제 및 PBS/glycerol 버퍼로 안정화되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:20–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2H4 |
| Immunogen | A synthesized peptide derived from human NUP98 (amino acids 1617–1635) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C or –80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898339 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is composed of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through synthesis and proteolytic cleavage of a 186 kDa precursor protein, resulting in both 98 kDa and 96 kDa nucleoporins localized to the nucleoplasmic side of the NPC.
Studies indicate that the 98 kDa nucleoporin functions as one of several docking site nucleoporins for transport substrates. The human NUP98 gene can fuse with several partner genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). It is located in the imprinted gene domain of 11p15.5, an important tumor-suppressor region associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and various cancers including lung, ovarian, and breast. Alternative splicing results in multiple transcript variants, not all of which are fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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