Thermo Fisher Scientific GRID2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide is homologous in rat and mouse.
• Specificity: GRID2.

Target Information

GRID2 is a member of the ionotropic glutamate receptor family, which are predominant excitatory neurotransmitter receptors in the mammalian brain.
This multi-pass membrane protein is selectively expressed in cerebellar Purkinje cells.
A point mutation in the mouse ortholog, associated with the “lurcher” phenotype, leads to ataxia due to apoptosis of Purkinje cells during postnatal development.
Homozygous mutations cause embryonic lethality with neuronal loss in mid- and hindbrain regions.
GRID2 also contributes to synapse organization between parallel fibers and Purkinje cells.
Alternative splicing produces multiple isoforms, and mutations in this gene are linked to cerebellar ataxia in humans.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.