Thermo Fisher Scientific GRIK5 Polyclonal Antibody

Thermo Fisher Scientific GRIK5 Polyclonal Antibody

Applications and Tested Dilution

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Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: GRIK5.

Target Information

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes.
Grik5, also known as kainate-preferring glutamate receptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels.
Grik5 is highly homologous to the related ionotrophic glutamate receptor Grik4 (KA1). Like Grik4, Grik5 does not form homomeric channels, but instead forms heteromers with Grik2.
In Grik2- but not Grik1- mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.