Thermo Fisher Scientific GABRA1 Polyclonal Antibody
GABRA1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합합니다. 사람, 마우스, 랫트에서 반응하며, 합성 펩타이드(aa 390–450)를 항원으로 사용했습니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000–1:3,000 | - |
| Immunohistochemistry (IHC) | 1:2,000–1:3,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 390–450 of human GABRA1 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity: GABA(A) receptor subunit alpha-1.
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing hyperpolarization through the opening of a Cl⁻ channel associated with the GABAA receptor subtype.
GABAA receptors are key targets for sedative, anxiolytic, and hypnotic agents and are implicated in diseases such as epilepsy, anxiety, depression, and substance abuse.
The GABAA receptor is a multimeric complex composed of multiple subunits (six alphas, four betas, four gammas, plus splice variants).
Expression of alpha and beta subunits alone produces GABA-sensitive receptors, but coexpression of gamma-subunits is required for benzodiazepine modulation.
Phosphorylation of beta-subunits modulates GABAA receptor function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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