Thermo Fisher Scientific VDR Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Flow Cytometry (Flow)

• Tested Dilution: 1:50–1:100

Product Specifications

Product Specific Information

Positive Control: PC-3M, Human small intestine tissue lysate, LOVO.

Target Information

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to DNA sequences after activation by the appropriate hormone.
The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the steroid hormone receptor superfamily, including estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors.
Vitamin D regulates calcium and phosphorus homeostasis, bone remodeling, cell growth, and differentiation.
VDR is found in intestine, bone, kidney, epidermis, and endocrine immune cells.
Repression of T-cell proliferation and IL-2 gene expression occurs when VDR binds within the IL-2 enhancer.
VDR/retinoic X receptor (RXR) heterodimer formation in the presence of intracellular 1,25(OH)₂D₃ interferes with NFATp/Fos/Jun/DNA complex assembly and IL-2 gene transcription.
The corresponding gene for the vitamin D receptor is NR1I1.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.