Thermo Fisher Scientific VDR Polyclonal Antibody
인간 VDR 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 유세포분석에 적합. 합성 펩타이드 면역원 기반으로 제작되었으며, PBS/glycerol 완충액에 보관. -20°C에서 보관하며 반복 동결/해동은 피해야 함.
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- PA51092xx (2개 옵션)
- 판매단위
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카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific VDR Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Flow Cytometry (Flow)
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within Human Vitamin D Receptor (aa 371–420) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles, store in dark |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2854647 |
Product Specific Information
Positive Control: PC-3M, Human small intestine tissue lysate, LOVO.
Target Information
Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to DNA sequences after activation by the appropriate hormone.
The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the steroid hormone receptor superfamily, including estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors.
Vitamin D regulates calcium and phosphorus homeostasis, bone remodeling, cell growth, and differentiation.
VDR is found in intestine, bone, kidney, epidermis, and endocrine immune cells.
Repression of T-cell proliferation and IL-2 gene expression occurs when VDR binds within the IL-2 enhancer.
VDR/retinoic X receptor (RXR) heterodimer formation in the presence of intracellular 1,25(OH)₂D₃ interferes with NFATp/Fos/Jun/DNA complex assembly and IL-2 gene transcription.
The corresponding gene for the vitamin D receptor is NR1I1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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