Thermo Fisher Scientific Tryptophan 5-hydroxylase 1, Tryptophan 5-hydroxylase 2 Polyclonal Antibody
인간, 마우스, 랫트 반응성을 가진 Rabbit Polyclonal 항체로 Tryptophan 5-hydroxylase 1/2 검출에 적합. WB, IHC, ICC, ELISA 등 다양한 응용 가능. 고순도 Protein A 정제, 안정적인 액상 형태로 연구용에 최적화.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Tryptophan 5-hydroxylase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin) (Martinez et al., 2001).
In mammals, serotonin biosynthesis occurs predominantly in neurons originating in the Raphe nuclei of the brain, while melatonin synthesis occurs in the pineal gland.
TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland.
The activity of TPH is enhanced by phosphorylation via cAMP-dependent protein kinase (PKA) and Ca²⁺/calmodulin kinase II (CAM K II) (Jiang et al., 2000; Johansen et al., 1996).
Both PKA and CAM K II phosphorylate Ser58 within the regulatory domain of TPH (Kuhn et al., 1997).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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