Thermo Fisher Scientific SIGLEC11 Polyclonal Antibody
인간 SIGLEC11 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용 가능. KLH 결합 합성 펩타이드(aa 251-350) 면역원 사용. 단백질 A로 정제된 액상 형태로, TBS buffer와 glycerol 포함. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human SIGLEC11, amino acids 251–350 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Siglecs are sialic acid-binding lectins of the immunoglobulin superfamily that are mainly expressed in cells of the hematopoietic system.
Siglec11 specifically binds to alpha2-8-linked sialic acids and is expressed on macrophages rather than peripheral blood leukocytes.
It shares high homology with Siglec10 in the extracellular domain but differs in the cytoplasmic domain, suggesting gene duplication and recombination in its evolution.
Upon pervanadate treatment, Siglec11 becomes tyrosine-phosphorylated and associates with SHP-1 and SHP-2.
At least five isoforms of Siglec11 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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