Thermo Fisher Scientific MAVS Polyclonal Antibody
MAVS 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간, 마우스, 랫트에 반응합니다. Western Blot, IHC, ICC/IF에 사용 가능하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 2–8°C에서 보관 가능합니다.
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Thermo Fisher Scientific MAVS Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide from near the center of human VISA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152620 |
Product Specific Information
A suggested positive control is rat brain tissue lysate.
PA5-20349 can be used with blocking peptide PEP-0469.
Target Information
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway relies on members of the Toll-like receptor (TLR) family, while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA to trigger the immune response.
MAVS is a mitochondrial membrane protein identified as a critical component in the IFN beta signaling pathway that recruits IRF-3 to RIG-I, leading to activation of NF-kappa-B. MAVS interacts with innate immune components such as TRIF, TRAF2, and TRAF6, and with kinases IKK-alpha, IKK-beta, and IKK-iota through its C-terminal region. Cleavage of this region by Hepatitis C virus (HCV) protease allows HCV to evade the host immune system. Multiple isoforms of MAVS are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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