Thermo Fisher Scientific Neuropoietin Monoclonal Antibody (321525)
마우스 Neuropoietin 단백질을 인식하는 Rat monoclonal 항체로, Western blot에 적합합니다. 단백질 A/G로 정제되었으며, PBS와 5% trehalose 용액에 동결건조 형태로 제공됩니다. -20°C에서 보관하며, 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 321525 |
| Immunogen | E. coli-derived recombinant mouse Neuropoietin/NP (Ala23–Ala204) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608238 |
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Neuropoietin is a newly identified member of the IL-6 cytokine family. Members of this family, including IL-6, IL-11, oncostatin M, leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, and CNTF, display a four-helix bundle structure and signal through gp130-containing receptor complexes.
Neuropoietin, predominantly expressed in neuroepithelia during embryonic life, acts through a receptor complex formed of CNTF receptor-alpha, gp130, and LIF receptor. Like CNTF, it promotes the survival of embryonic motor neurons and can increase the proliferation of neural precursor cells in the presence of EGF and FGF-2.
Interestingly, the human neuropoietin gene has evolved toward a pseudogene, suggesting that alternative signaling via CNTF is an effective compensatory pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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