Thermo Fisher Scientific DAND5 Monoclonal Antibody (322206)

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

322206

Immunogen

E. coli-derived recombinant human COCO Arg23-Ala189 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DAND5,uniProtId:Q8N907-1,ncbiNodeId:9606,antigenRange:23-189,antigenLength:189,antigenImageFileName:MA5-24045_DAND5_Q8N907-1_House_mouse.svg,antigenImageFileNamePDP:MA5-24045_DAND5_Q8N907-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2606623

Product Specific Information

In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse (rm) COCO, rmGremlin, rmPRDC, recombinant human (rh) DAN, rhCerberus, or recombinant chicken Caronte is observed.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.