Thermo Fisher Scientific CD35/CR1 (Follicular Dendritic Cell Marker) Monoclonal Antibody (CR1/6383)
CD35/CR1 단클론 항체로 여포 수지상세포(FDC) 마커로 사용됩니다. 인간 시료에 반응하며, IHC(P)와 Peptide Array에 적합합니다. CD35 단백질의 C3b/C4b 결합 수용체 기능 연구 및 B세포 관련 종양 분석에 유용합니다.
- 카탈로그번호
- 1378-MSM13-P1
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CR1/6383 |
| Immunogen | Recombinant fragment (within aa650–850) of human CD35 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Stability: Antibody is stable for 24 months.
- Positive Control: Follicular dendritic cells (FDC) in tonsil.
- Cellular Localization: Cell surface
Specificity Comments:
CD35 (complement receptor 1) is a membrane-bound monomeric glycoprotein expressed on erythrocytes, leukocytes, glomerular podocytes, and follicular dendritic cells. It acts as a receptor for C3b and C4b, key components of the complement system involved in the clearance of foreign macromolecules. CD35 is found on erythrocytes, B cells, subsets of T cells, monocytes, eosinophils, and neutrophils. Anti-CD35 serves as a mature B-cell marker labeling follicular dendritic reticulum cells and related tumors such as follicular dendritic cell tumor/sarcoma.
Target Information
CD35 (CR1, Complement Receptor 1) is a cell membrane-bound glycoprotein that serves as the receptor for C3b and C4b, facilitating the clearance of immune complexes. It mediates cellular binding to complement-activated particles and immune complexes. CD35 exists in four allotypes (C, A, B, D) with molecular weights of approximately 160, 190, 220, and 250 kDa, respectively. It is involved in immune complex processing, phagocytosis of C3b complexes, and inhibition of complement activation.
CD35 is expressed on neutrophils, eosinophils, monocytes, B cells, some NK cells, erythrocytes, myeloid leukemias, and follicular dendritic reticulum cells, but not on basophils. Reduced expression or mutations in CD35 are associated with diseases such as gallbladder carcinoma, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, and sarcoidosis. Certain mutations may reduce Plasmodium falciparum rosetting, offering protection against severe malaria. Alternate splice variants and a secreted form of CD35 have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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