Thermo Fisher Scientific Phospho-FGFR1/FGFR2 (Tyr463, Tyr466) Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

1:100-1:500

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human FGFR1/2 around the phosphorylation site of Tyr463/466. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FGFR1/FGFR2,uniProtId:P11362-1,ncbiNodeId:9606,antigenRange:463,antigenLength:822,antigenImageFileName:PA5-118586_FGFR1FGFR2_P11362-1_Rabbit.svg,antigenImageFileNamePDP:PA5-118586_FGFR1FGFR2_P11362-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:FGFR1/FGFR2,uniProtId:P21802-1,ncbiNodeId:9606,antigenRange:466,antigenLength:821,antigenImageFileName:PA5-118586_FGFR1FGFR2_P21802-1_Rabbit.svg,antigenImageFileNamePDP:PA5-118586_FGFR1FGFR2_P21802-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2903086

Product Specific Information

Antibody detects endogenous levels of FGFR1/2 only when phosphorylated at Tyr463/466.

Target Information

FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.