Thermo Fisher Scientific Bim Monoclonal Antibody (K.912.7)
Thermo Fisher Scientific의 Bim Monoclonal Antibody (K.912.7)는 인간, 마우스, 랫트에 반응하는 Rabbit IgG 형 단일클론 항체로, Western blot, IHC, ICC/IF 등 다양한 응용에 적합합니다. BCL-2 패밀리 단백질 연구용으로 사용되며, 액상 형태로 -20°C 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:400 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 | - |
| Flow Cytometry (Flow) | 1:100–1:400 | - |
| Immunoprecipitation (IP) | 1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | K.912.7 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Pro25 of Bim |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 88 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10981505 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
BIM belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It interacts with other BCL-2 family members, including BCL2, BCL2L1/BCL-X(L), and MCL1, acting as an apoptotic activator. Expression can be induced by nerve growth factor (NGF) and forkhead transcription factor FKHR-L1, suggesting a role in neuronal and lymphocyte apoptosis. Mouse transgenic studies indicate that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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