Thermo Fisher Scientific Sp1 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Predicted to react with Mouse, X. laevis, X. tropicalis, Chicken, Goat, Bovine, Dog, Horse, Rabbit, Pig, Panda, Orangutan, Monkey, and Gorilla

Target Information

SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. It binds with high affinity to GC-rich motifs and regulates the expression of numerous genes involved in processes such as cell growth, apoptosis, differentiation, and immune responses. SP1 activity is highly regulated by post-translational modifications including phosphorylation, sumoylation, proteolytic cleavage, glycosylation, and acetylation. It also binds the PDGFR-alpha G-box promoter and may modulate cellular response to DNA damage. SP1 is implicated in chromatin remodeling and plays a role in recruiting SMARCA4/BRG1 on the c-FOS promoter and in regulating FE65 gene expression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: IHC-00208_SP1_P08047-1_Rabbit_PDP.jpeg)