Thermo Fisher Scientific Nurr1 Polyclonal Antibody
Rabbit 유래의 Nurr1 단클론 항체로 Western blot과 IHC에 적합. Nurr1 단백질의 513-526 아미노산 서열을 항원으로 제작됨. 도파민 신경계 연구 및 파킨슨병 관련 연구에 활용 가능. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (IHC) | 1:100–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide comprising residues 513–526 [TERHGLKEPKRVEE] of the human Nurr1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4 °C short term. For long term storage, store at −20 °C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Target Information
The Nuclear receptor related 1 protein (Nurr1), also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2), is a protein encoded by the NR4A2 gene in humans. NURR1 is a member of the nuclear receptor family of intracellular transcription factors and plays a key role in the maintenance of the dopaminergic system of the brain. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson’s disease, schizophrenia, and manic depression. Misregulation of this gene may also be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full-length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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