Thermo Fisher Scientific Estrogen Receptor alpha Monoclonal Antibody (TE111.5D11)
Estrogen Receptor alpha 단클론 항체(TE111.5D11)는 인간 및 다양한 종에서 반응하며, WB, IHC, ICC, IP, ChIP 등 여러 응용에 적합합니다. Protein A/G로 정제된 액상형 항체로, 안정적인 -20°C 보관이 가능합니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 16 publications |
| Immunohistochemistry (IHC) | – | View 7 publications |
| Immunocytochemistry (ICC/IF) | – | View 3 publications |
| Flow Cytometry (Flow) | – | View 1 publication |
| Immunoprecipitation (IP) | 2 µg/mL protein lysate | View 8 publications |
| ChIP assay (ChIP) | Assay-dependent | View 21 publications |
| Neutralization (Neu) | – | View 1 publication |
| Gel Shift (GS) | Assay-dependent | View 4 publications |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Bovine, Dog, Chicken, Hamster, Human, Mouse, Sheep, Pig, Rabbit, Rat |
| Published Species | Bovine, Chicken, Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TE111.5D11 |
| Immunogen | C-terminal fragment (aa 302–595) of human ER expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS |
| Contains | 0.08% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1074278 |
Product Specific Information
A suggested positive control for this product is T47D cells.
Target Information
Estrogen Receptors (ER) belong to the steroid/thyroid hormone receptor superfamily of nuclear receptors. They act as ligand-activated transcription factors that, upon estrogen binding, dimerize and bind to estrogen response elements (EREs) in DNA to regulate gene expression via coactivators or corepressors.
Two forms of ER exist—alpha (ESR1) and beta (ESR2)—with multiple alpha isoforms (66, 53, 47, and 35 kDa). ERs are widely expressed across tissues and play key roles in sexual development, reproduction, and bone health. They are also implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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