Thermo Fisher Scientific Tau Recombinant Rabbit Monoclonal Antibody (SD205-09)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Control: SH-SY5Y, HeLa, SHG-44
• Subcellular Location: Cytoplasm, Cell membrane, Cell projection

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. Its primary function is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules, while the N-terminus interacts with neural plasma membrane components, suggesting Tau acts as a linker between these structures.

Axonal polarity is determined by Tau/MAPT localization within the neuronal cell body domain defined by the centrosome. Short isoforms contribute to cytoskeletal plasticity, while longer isoforms provide structural stability.

In its hyper-phosphorylated form, Tau forms paired helical filaments (PHF), the building blocks of neurofibrillary lesions characteristic of Alzheimer’s disease (AD). Hyper-phosphorylation disrupts Tau’s microtubule-binding function, leading to destabilization and neuronal degeneration. Multiple kinases, including GSK-3β, PKA, cdk5, and casein kinase II, are known to phosphorylate Tau. Hyper-phosphorylated Tau is also found in neurofibrillary lesions associated with other CNS disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지