Thermo Fisher Scientific STAT5 beta Recombinant Rabbit Monoclonal Antibody (SD08-08)
STAT5 beta 단백질을 표적으로 하는 토끼 단클론 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, HEK293 세포에서 발현된 재조합 항체입니다. 단백질 A로 정제되었으며, 연구용으로 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SD08-08 |
| Immunogen | Recombinant protein within C-terminal mouse STAT5b |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2911596 |
Product Specific Information
- Positive Control: Hela cell lysate, RH-35 cell lysate, Hela, PC-3M, RH-35, human breast carcinoma tissue, mouse colon tissue, human spleen tissue, mouse testis tissue
- Subcellular Location: Cytoplasm, Nucleus
Target Information
The STAT5 beta protein is a member of the STAT family of transcription factors. Upon stimulation by cytokines and growth factors, STAT proteins are phosphorylated by receptor-associated kinases, forming homo- or heterodimers that translocate to the nucleus to act as transcription activators. STAT5 beta mediates signaling from ligands such as IL2, IL4, CSF1, and various growth hormones. It plays roles in TCR signaling, apoptosis, mammary gland development, and liver gene expression dimorphism. Dysregulation of STAT5 beta signaling has been implicated in certain acute promyelocytic leukemias (APLL) involving fusion with the RARA gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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