Thermo Fisher Scientific OTUD7B Monoclonal Antibody (OTI3D10), TrueMAB
OTUD7B 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 적합합니다. 인간, 생쥐, 랫트 반응성이 있으며, Lyophilized 형태로 제공됩니다. NF-kappa-B 경로 조절 및 T세포 반응 연구에 유용합니다.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3D10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 449–729 of human OTUD7B produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
OTUD7B acts as a negative regulator of the non-canonical NF-kappa-B pathway by mediating deubiquitination of TRAF3, preventing its degradation and overactivation of NF-kappa-B signaling. It regulates B-cell and T-cell responses, mucosal immunity, and deubiquitinates key signaling molecules such as ZAP70 and EGFR.
OTUD7B exhibits deubiquitinating activity toward Lys-11, Lys-48, and Lys-63-linked polyubiquitin chains, with higher catalytic activity for Lys-11-linked chains.
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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