Thermo Fisher Scientific DUSP12 Polyclonal Antibody
Human DUSP12 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol 버퍼에 보관됩니다. 연구용으로 MAPK 신호 조절 관련 연구에 활용 가능합니다.
- 판매단위
- pk
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Thermo Fisher Scientific DUSP12 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human DUSP12. Recombinant protein control fragment (Product #RP-89148) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2856164 |
Product Specific Information
Immunogen sequence:
YQAMGYEVDT SSAIYKQYRL QKVTEKYPEL QNLPQELFAV DPTTVSQGLK DEVLYKCRKC RRSLFRSSSI LDHREGSGPI AFAHKRMTPS SMLTTGRQAQ CTSYFIEPVQ WMESALLGVM DGQLLCPKCS AKLGSFNWYG EQCSCGRWI
Target Information
Dual specificity phosphatases (DUSPs) inactivate their target kinases by dephosphorylating both phosphoserine/threonine and phosphotyrosine residues.
DUSPs are divided into six subgroups based on sequence similarity: PRLs, Cdc14 phosphatases, PTENs, myotubularins, MKPs, and atypical DUSPs.
DUSP inhibitors may manipulate MAPK and cellular responses in both positive and negative ways.
DUSP family members regulate MAPK intensity and duration to determine physiological responses.
DUSP12 (YVH1, GKAP) contains a consensus DUSP catalytic domain and an extended C-terminal domain of unknown function, possibly related to glucokinase regulation. It is localized in the cytoplasm and nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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