Thermo Fisher Scientific p47ING3 Polyclonal Antibody
Human ING3 단백질을 인식하는 염소 폴리클로날 항체로, Western blot, ELISA, Immunoprecipitation에 적합합니다. 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다. -20°C에서 보관하며 반복적인 동결-해동을 피하십시오.
- 카탈로그번호
- 600-101-283
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific p47ING3 Polyclonal Antibody
Thermo Fisher Scientific p47ING3 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:10,000 |
| ELISA | 1:10,000–1:40,000 |
| Immunoprecipitation (IP) | 1:200–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Affinity-purified antibody from goat serum immunized with a synthetic peptide corresponding to aa 285–310 of Human ING3 protein (Inhibitor of growth family, member 3). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02 M potassium phosphate, pH 7.2, with 0.15 M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid repeated freeze/thaw cycles.
- Centrifuge if not clear after standing at room temperature.
- Stable for several weeks at 4°C as undiluted liquid.
- Dilute only prior to immediate use.
Reactivity occurs against human p47 ING3 protein. This sequence shows homology only to isoform 1 of ING3 and not to isoforms 2 or 3. 100% homology is recorded for human, dog, rat, chimpanzee, and orangutan. Cross-reactivity with mouse and chicken p47 ING3 is expected based on BLAST analysis (one amino acid difference). Reactivity with other species is unknown.
Target Information
The ING3 gene encodes a protein similar to ING1, a tumor suppressor interacting with TP53, inhibiting cell growth, and inducing apoptosis. It contains a PHD-finger motif associated with chromatin remodeling. ING3 activates p53-dependent promoters such as p21/waf1 and bax. Overexpression inhibits cell growth and induces apoptosis. Allelic loss and reduced expression are observed in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.