Thermo Fisher Scientific Aurora B Monoclonal Antibody (AURKB, 1521)
Aurora B 단백질을 인식하는 마우스 모노클로날 항체로 Western blot에 적합합니다. 인간 시료에 반응하며, Protein A/G로 정제된 액상 형태입니다. 세포 분열 관련 연구 및 Aurora kinase 신호 분석에 유용합니다.
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Applications
- Western Blot (WB): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AURKB, 1521 |
| Immunogen | Recombinant fragment (around aa 89–251) of human Aurora B protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Aurora kinases are associated with microtubules during chromosome movement and segregation. AURKB (Aurora B) localizes to microtubules near kinetochores, specifically to specialized microtubules called K-fibers. This complex functions in chromosome alignment and separation, histone modification, and cytokinesis.
The Chromosomal Passenger Complex (CPC) includes three non-enzymatic subunits — INCENP, survivin, and borealin — which determine the activity, localization, and stability of Aurora B. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and Aurora B. The quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP–AurB complex may be responsible for histone H3 modification.
AurB is overexpressed in several tumors, including primary breast and colon cancers, and its expression is linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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