Thermo Fisher Scientific Met (c Met) Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal Anti-Met (c-Met) 항체. Western blot과 ELISA에 적합하며 Protein A로 정제된 액상 형태. TBS buffer에 BSA 및 glycerol 포함, -20°C 보관 권장. 암 연구 및 신호전달 경로 분석에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Met (c-Met), amino acids 801–900 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MET (c-MET) is a receptor-like tyrosine kinase whose dysregulation has been linked to various human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, leading to activation of signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
MET is involved in embryonic development processes including gastrulation, muscle and neuron development, angiogenesis, and kidney formation. In adults, it contributes to wound healing, organ regeneration, and tissue remodeling.
Aberrant MET signaling has been associated with cancers including gastric, renal, and breast cancers, making it an important target for cancer therapeutics and diagnostic research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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