ELK Biotechnology Caspase-4 rabbit pAb
인간 Caspase-4 단백질을 인식하는 토끼 폴리클로날 항체. WB, IHC, IF, ELISA에 사용 가능하며, 세포자멸사 연구에 적합. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관 가능.
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제품명
Caspase-4 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CASP4; ICH2; Caspase-4; CASP-4; ICE(rel)-II; Protease ICH-2; Protease TX |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Caspase-4 (AA range: 75–124) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 45 kD |
| GeneID (Human) | 837 |
| Human Swiss-Prot No | P49662 |
| Cellular Localization | Cytoplasm, cytosol, endoplasmic reticulum membrane (peripheral membrane protein, cytoplasmic side), mitochondrion, inflammasome, secreted. Predominantly localizes to the ER. Association with ER membrane requires TMEM214 (PubMed:15123740). Released in extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630). |
| Species Reactivity | Human |
Background
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme. This caspase can cleave and activate its own precursor as well as caspase-1 precursor. Overexpression induces apoptosis. Alternative splicing results in distinct isoforms.
[provided by RefSeq, Jul 2008]
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