ELK Biotechnology ZAP-70 (phospho Tyr292) rabbit pAb
인간 및 마우스에 반응하는 ZAP-70 (phospho Tyr292) rabbit polyclonal antibody로, T세포 신호전달 관련 단백질 검출에 적합. WB 및 ELISA에 사용 가능하며, 고순도 IgG 형태로 안정적 저장 가능. TCR 활성화 및 면역학 연구에 유용.
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제품명
ZAP-70 (phospho Tyr292) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ZAP70; SRK; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ZAP-70 around the phosphorylation site of Tyr292 (AA range: 258–307) |
| Species Reactivity | Human; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 70 kDa |
| GeneID (Human) | 7535 |
| Human Swiss-Prot No | P43403 |
| Cellular Localization | Cytoplasm; Cell membrane; Peripheral membrane protein. In quiescent T-lymphocytes, it is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD247/CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in thymocytes (By similarity). |
| Storage | -20°C / 1 year |
| Host | Rabbit |
Background
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases Lck and Fyn. It is essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)
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