ELK Biotechnology Troponin I-C (phospho Ser43) rabbit pAb
Troponin I-C (phospho Ser43) rabbit polyclonal antibody로, 인산화된 Ser43 부위를 인식합니다. WB, IHC, IF, ELISA에 사용 가능하며, 사람, 마우스, 랫트에 반응합니다. 심근 단백질 연구 및 심근 손상 관련 연구에 적합합니다.
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Troponin I-C (phospho Ser43) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Troponin I-C (phospho Ser43) rabbit pAb |
| Alternative Names | TNNI3; TNNC1; Troponin I; cardiac muscle; Cardiac troponin I |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TNNI3 around the phosphorylation site of Ser43. AA range: 11–60 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 26 kD |
| GeneID (Human) | 7137 |
| Human Swiss-Prot No. | P19429 |
| Cellular Localization | Cytosol, troponin complex, sarcomere |
| Species Reactivity | Human; Mouse; Rat |
Background
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of three subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
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