ELK Biotechnology Cleaved-Caspase-1 p20 (D210) rabbit pAb
Cleaved-Caspase-1 p20 (D210) rabbit polyclonal antibody. 인간, 마우스, 랫트 시료에 반응하며 WB, IF, IHC, ELISA에 사용 가능. Caspase-1 활성화 단백질 검출용. 세포자멸사 연구 및 염증 반응 분석에 적합.
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Cleaved-Caspase-1 p20 (D210) rabbit pAb
제품 개요
Cleaved-Caspase-1 p20 (D210) rabbit polyclonal antibody는 Caspase-1 단백질의 절단형(p20 fragment)을 인식하는 항체로, 세포자멸사(apoptosis) 및 염증 관련 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Cleaved-Caspase-1 p20 (D210) rabbit pAb |
| Alternative Names | CASP1; IL1BC; IL1BCE; Caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45 |
| Applications | WB; IF; IHC; ELISA |
| Recommended Dilutions | WB 1:500–2000, IHC-p 1:50–300, IF 1:50–300 |
| Immunogen | Synthesized peptide derived from human Caspase-1 (AA range: 161–210) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 25 kDa |
| Gene ID (Human) | 834 |
| Human Swiss-Prot No. | P29466 |
| Cellular Localization | Cytoplasm, Cell membrane |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes a protein that belongs to the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits (large and small) that dimerize to form the active enzyme.
Caspase-1 is known for its ability to cleave and activate the inactive precursor of interleukin-1, a cytokine involved in inflammation, septic shock, and wound healing. It has been shown to induce apoptosis and may function in various developmental stages. Studies in mouse models suggest a role in the pathogenesis of Huntington’s disease.
Alternative splicing results in transcript variants encoding distinct isoforms. (RefSeq, Mar 2012)
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