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ELK Biotechnology BUB1 rabbit pAb
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BUB1 단백질을 인식하는 토끼 다클론 항체로, Western Blot 및 ELISA에 적합합니다. 인산화 효소로서 세포 분열 체크포인트 조절에 관여하는 BUB1 단백질 검출에 사용됩니다. 사람, 생쥐, 랫트 시료에서 반응하며 핵 및 키네토코어에 주로 위치합니다.
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ELK Biotechnology ES7356-100UL BUB1 rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES7356-50UL BUB1 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology BUB1 rabbit pAb
제품명
BUB1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | BUB1; BUB1L; Mitotic checkpoint serine/threonine-protein kinase BUB1; hBUB1; BUB1A |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BUB1. AA range: 781–830 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 120 kD |
| Gene ID (Human) | 699 |
| Human Swiss-Prot No. | O43683 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Nucleus; Chromosome (centromere, kinetochore). Nuclear in interphase cells. Accumulates during G1 and S phase, peaks at G2/M, and drops after mitosis. Localizes to the outer kinetochore. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage and occurs early in prophase. AURKB, KNL1, and INCENP are required for kinetochore localization (By similarity). |
| Background | This gene encodes a serine/threonine-protein kinase that plays a central role in mitosis. It functions by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. It also inhibits activation of the anaphase promoting complex/cyclosome and may function in DNA damage response. Mutations are associated with aneuploidy and several cancers. Alternate splicing results in multiple transcript variants. [RefSeq, Jul 2013] |
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