ELK Biotechnology Stat5a/b (phospho Ser726/731) rabbit pAb
STAT5A/B 인산화(Ser726/731) 부위를 인식하는 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 적합. 인간, 마우스, 랫트 반응성. 세포 내 인산화 반응 연구 및 신호전달 경로 분석에 활용 가능.
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제품명
Stat5a/b (phospho Ser726/731) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | STAT5A; STAT5; Signal transducer and activator of transcription 5A; STAT5B; Signal transducer and activator of transcription 5B |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human STAT5A/B around the phosphorylation site of Ser725/730 (AA range: 696–745) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 91 kDa |
| Gene ID (Human) | 6776 / 6777 |
| Human Swiss-Prot No | P42229 / P51692 |
| Cellular Localization | Cytoplasm, Nucleus. Translocates into the nucleus in response to phosphorylation. |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases and then form homo- or heterodimers that translocate to the cell nucleus, where they act as transcription activators. This protein mediates responses to ligands such as IL2, IL3, IL7, GM-CSF, erythropoietin, thrombopoietin, and various growth hormones. Activation in myeloma and lymphoma associated with TEL/JAK2 gene fusion is independent of cell stimulus and is essential for tumorigenesis. The mouse counterpart induces expression of BCL2L1/BCL-X(L), suggesting an anti-apoptotic function. Alternatively spliced transcript variants have been identified.
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