ELK Biotechnology BRCA2 (phospho Ser3291) rabbit pAb
BRCA2 단백질의 Ser3291 인산화 형태를 인식하는 rabbit polyclonal antibody. WB 및 ELISA에 적합하며, 유방암 및 DNA 복구 관련 연구에 활용 가능. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 보관.
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BRCA2 (phospho Ser3291) Rabbit pAb
제품 개요
BRCA2 단백질의 Ser3291 인산화 부위를 인식하는 rabbit polyclonal antibody로, 유방암 및 DNA 복구 관련 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | BRCA2 (phospho Ser3291) rabbit pAb |
| Alternative Names | BRCA2; FACD; FANCD1; Breast cancer type 2 susceptibility protein; Fanconi anemia group D1 protein |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human BRCA2 (phospho Ser3291) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 385 kD |
| GeneID (Human) | 675 |
| Human Swiss-Prot No | P51587 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Nucleus; Cytoplasm; Cytoskeleton; Microtubule organizing center; Centrosome. Colocalizes with ERCC5/XPG to nuclear foci following DNA replication stress. |
Background
Inherited mutations in BRCA1 and BRCA2 confer increased lifetime risk of developing breast or ovarian cancer.
Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair.
The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, which mediates binding to the RAD51 recombinase functioning in DNA repair.
BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
[provided by RefSeq, Dec 2008]
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