Thermo Fisher Scientific CD200 Monoclonal Antibody (OX90), PerCP-eFluor 710, eBioscience
Flow cytometry용 Mouse CD200(OX2) 검출용 Rat monoclonal antibody. PerCP-eFluor 710 형광 표지로 Blue laser(488 nm)에서 710 nm 방출. 높은 특이성과 안정성, 다양한 세포 분석에 적합. 연구용 시약으로 진단용 아님.
- 카탈로그번호
- 46-5200-8x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD200 Monoclonal Antibody (OX90), PerCP-eFluor 710, eBioscience
Thermo Fisher Scientific CD200 Monoclonal Antibody (OX90), PerCP-eFluor 710, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 0.125 µg/test
Publications: View 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host/Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), PerCP-eFluor™ 710, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OX90 |
| Conjugate | PerCP-eFluor™ 710 |
| Excitation/Emission Max | 482 / 708 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10596804 |
Additional Formats
Product Specific Information
The monoclonal antibody OX90.1 recognizes mouse CD200 (OX2), a member of the Ig superfamily with two Ig domains, a transmembrane and cytoplasmic domain.
CD200 is expressed on resting and activated B cells, subsets of T cells, keratinocytes, peripheral and central nerve cells, follicular dendritic cells, and ovarian cells.
Interaction with CD200R results in macrophage activation (IL-6 production), inhibition of mast cell degranulation, reduced TNF-α and IL-13 secretion, and attenuation of lymphocyte activation.
Applications Reported: Flow cytometric analysis.
Applications Tested: Tested with mouse splenocytes at ≤0.125 µg/test (100 µL final volume). Optimal titration recommended.
Fluorochrome Information:
PerCP-eFluor® 710 can replace PE-Cy5, PE-Cy5.5, or PerCP-Cy5.5.
- Excitation: 488 nm (Blue laser)
- Emission: 710 nm
- Recommended filters: 685 LP dichroic mirror + 710/40 band pass (or 695/40 BP alternative)
PerCP-eFluor® 710 conjugated antibodies are stable when samples are fixed with freshly prepared 2% formaldehyde overnight at 4°C.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD200 is a type-1 membrane glycoprotein with two immunoglobulin domains, belonging to the Ig superfamily.
It interacts with CD200R on myeloid cells to inhibit macrophage activation.
Homologues are found in herpesviruses and poxviruses.
Studies suggest CD200 regulates myeloid cell activity and provides inhibitory signals to macrophages across tissues.
Associated diseases include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy.
Multiple alternatively spliced transcript variants exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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