Thermo Fisher Scientific BRAF Monoclonal Antibody (OTI4G6), TrueMAB
BRAF 단백질을 인식하는 Mouse monoclonal antibody로 Western blot과 Immunoprecipitation에 적합. Human 시료 반응성. Lyophilized 형태로 제공되며 PBS buffer에 8% trehalose 포함. 연구용으로 세포 신호전달 및 암 관련 연구에 활용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4G6 |
| Immunogen | Full-length protein expressed in 293T cell transfected with human BRAF expression vector |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
BRAF is involved in transducing mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutations in human cancers and plays a role in postsynaptic responses of hippocampal neurons.
This protein regulates the MAP kinase/ERKs signaling pathway, influencing cell division, differentiation, and secretion.
Mutations in BRAF are associated with cancers such as non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and lung adenocarcinoma. A pseudogene located on chromosome X has also been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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