Thermo Fisher Scientific CD43 Recombinant Mouse Monoclonal Antibody (rSPN, 1094)
CD43 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 마우스 단일클론 항체. WB, IHC, ICC/IF, Flow Cytometry에 사용 가능. HEK293 세포에서 발현된 IgG1, kappa 형 항체로, 고순도 Protein A/G 정제 및 PBS 버퍼에 저장. 연구용 한정 제품.
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- 6693-MSM8-P1ABX
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- pk
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Thermo Fisher Scientific CD43 Recombinant Mouse Monoclonal Antibody (rSPN, 1094)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rSPN, 1094 |
| Immunogen | Recombinant full-length human CD43 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with a high negative charge, expressed on the surface of most hematopoietic cells.
It acts as a repulsive barrier interfering with cellular adhesion and can promote leukocyte aggregation.
By interacting with actin-binding proteins ezrin and moesin, CD43 regulates T-cell morphology and cell-cell interactions during lymphocyte traffic.
CD43 signaling enhances LFA-1 adhesiveness while counteracting its induction via other receptors.
Expression of CD43 induces functionally active tumor suppressor p53 protein, but in p53 and ARF deficiency, CD43 promotes tumor proliferation and viability.
CD43 is an important modulator of leukocyte functions.
Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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