Thermo Fisher Scientific TMED10/TMP21 Polyclonal Antibody
TMED10/TMP21 단백질을 인식하는 Rabbit Polyclonal 항체로 Western Blot 및 Immunoprecipitation에 사용 가능. Human 및 Mouse 반응성. 항원 친화 크로마토그래피로 정제된 액상형 제품이며, 4°C 보관 권장. Alzheimer 연구 등 단백질 수송 및 γ-secretase 조절 연구에 활용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 50 to 100 of Human Transmembrane emp24 domain-containing protein 10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is also a component of the presenilin complex and modulates the γ-secretase but not the ε-secretase cleavage activity of the amyloid precursor protein.
The presenilin complex includes APH1, nicastrin, PEN2, and presenilin-1, which together cleave amyloid precursor protein at γ- and ε-sites. This process can lead to accumulation of the Aβ cleavage product associated with Alzheimer’s disease.
Co-immunoprecipitation experiments indicate TMP21 may regulate this complex. Suppression of TMP21 expression by siRNA increases γ-secretase activity and Aβ production, demonstrating TMP21’s modulatory role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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