Thermo Fisher Scientific TMED10/TMP21 Polyclonal Antibody
Rabbit에서 생성된 TMED10/TMP21 폴리클로날 항체로, 인간 TMP21 단백질(50–100번 잔기 영역)을 면역원으로 사용. Western blot 및 Immunoprecipitation에 적합하며, 액상 형태로 1 mg/mL 농도. 4°C 보관, 연구용으로만 사용.
- 카탈로그번호
- A305228Ax (2개 옵션)
- 판매단위
- pk
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TMED10/TMP21 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 50 to 100 of Human Transmembrane emp24 domain-containing protein 10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is also a component of the presenilin complex and modulates the γ-secretase but not the ε-secretase cleavage activity of amyloid precursor protein.
The presenilin complex consists of APH1, nicastrin, PEN2, and presenilin-1, and is responsible for cleavage of amyloid precursor protein at γ- and ε-sites, which can lead to accumulation of Abeta associated with Alzheimer’s disease.
Co-immunoprecipitation experiments have shown TMP21 interacts with these proteins, suggesting a regulatory role. Suppression of TMP21 expression by siRNA increases γ-secretase activity and Abeta production, demonstrating TMP21’s modulatory function.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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