Thermo Fisher Scientific TMED10/TMP21 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Orangutan

Target Information

TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is also a component of the presenilin complex and modulates the γ-secretase but not the ε-secretase cleavage activity of amyloid precursor protein.
The presenilin complex consists of APH1, nicastrin, PEN2, and presenilin-1, and is responsible for cleavage of amyloid precursor protein at γ- and ε-sites, which can lead to accumulation of Abeta associated with Alzheimer’s disease.
Co-immunoprecipitation experiments have shown TMP21 interacts with these proteins, suggesting a regulatory role. Suppression of TMP21 expression by siRNA increases γ-secretase activity and Abeta production, demonstrating TMP21’s modulatory function.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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